Figure 4.

Mean (±SEM) (n = 3) size (a) and PDI (b) of nanoparticles with a range of theoretical drug loadings (0, 5, 10, and 20%) fabricated using 1% PLGA in DCM using a low side/centre flow rate ratio (60/4.5). The mean size of nanoparticles increased with increased drug loading, with this effect most marked at 20% peptide loading (0 < 5 < 10 < 20%). The PDI was significantly decreased for particles containing 5% peptide (<0.4) compared with blank nanoparticles (0.8). PDI increased with increased drug loading (5 < 10 < 20%). One-way ANOVA analysis followed by Tukey test for multiple comparisons (** p < 0.01; and ns, no significant difference).