Table 4.
C20:4 | MUFA | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Single-Marker Analysis | Conditional Analysis | Single-Marker Analysis | Conditional Analysis | |||||||||
No | 1 BP | SNP annotation | 2 Allele 1 | 3 r | 4 b | 5p-value | 6 β | 7p-value | 4 b | 5p-value | 6 β | 7p-value |
1 | 12:54812172 | intron-GAS7 | T | −0.443 | 0.145 | 3.30 × 10−11 | 0.031 | 0.164 | −1.021 | 4.32 × 10−7 | 0.204 | 0.694 |
2 | 12:54842795 | intron-GAS7 | T | 0.390 | −0.089 | 0.0003 | 0.025 | 0.324 | 0.543 | 0.0197 | 0.234 | 0.060 |
3 | 12:54901488 | intron-GAS7 | G | −0.382 | 0.076 | 0.0002 | −0.004 | 0.861 | −0.572 | 0.0033 | 0.195 | 0.537 |
4 | 12:54929793 | intron-GAS7 | G | 0.638 | 0.182 | 2.24 × 10−22 | 0.050 | 0.010 | −1.458 | 1.80 × 10−17 | 0.176 | 0.027 |
5 | 12:54956054 | intron-GAS7 | C | *- | −0.305 | 9.66 × 10−42 | **- | **- | 2.404 | 3.30 × 10−31 | **- | **- |
6 | 12:55073130 | coding-MYH13 | A | −0.581 | 0.154 | 1.43 × 10−12 | −0.003 | 0.909 | −1.108 | 5.52 × 10−8 | 0.191 | 0.354 |
7 | 12:55093697 | intron MYH13 | A | −0.354 | 0.059 | 0.014 | −0.031 | 0.193 | −0.479 | 0.032 | 0.294 | 0.189 |
8 | 12:55120479 | 3′UTR MYH8 | G | −0.548 | 0.157 | 1.32 × 10−13 | 0.016 | 0.452 | −1.389 | 1.59 × 10−12 | −0.202 | 0.314 |
9 | 12:55180513 | 3′UTR MYH4 | G | −0.556 | 0.160 | 1.19 × 10−14 | 0.022 | 0.310 | −1.383 | 6.56 × 10−13 | −0.222 | 0.260 |
10 | 12:55229376 | exon MYH2 | G | 0.996 | −0.289 | 2.77 × 10−38 | † NA | † NA | 2.302 | 3.74 × 10−29 | † NA | † NA |
11 | 12:55262653 | exon MYH2 | T | 0.996 | −0.299 | 2.58 × 10−40 | † NA | † NA | 2.357 | 3.50 × 10−30 | † NA | † NA |
12 | 12:55351879 | intron MYH3 | A | 0.702 | 0.209 | 6.64 × 10−23 | 0.018 | 0.421 | −1.613 | 3.45 × 10−16 | −0.066 | 0.745 |
13 | 12:55373617 | 5′UTR MYH3 | G | 0.866 | −0.272 | 8.39 × 10−32 | −0.022 | 0.383 | 2.025 | 3.13 × 10−21 | 0.054 | 0.809 |
14 | 12:55373707 | 5′UTR MYH3 | 2 | 0.999 | −0.301 | 5.67 × 10−41 | † NA | † NA | 2.381 | 7.35 × 10−31 | † NA | † NA |
15 | 12:55447604 | intron ADPRM | G | 0.626 | −0.228 | 3.51 × 10−15 | −0.016 | 0.586 | 1.836 | 1.09 × 10−11 | 0.053 | 0.849 |
16 | 12:55463919 | intron ADPRM | G | 0.946 | −0.291 | 5.64 × 10−38 | −0.008 | 0.758 | 2.348 | 1.23 × 10−29 | 0.120 | 0.587 |
17 | 12:55475542 | intron ADPRM | T | −0.630 | 0.178 | 4.09 × 10−21 | 0.045 | 0.020 | −1.404 | 5.31 × 10−16 | −0.328 | 0.064 |
18 | 12:55530321 | intron ENSSSCG 00000044652 |
A | −0.101 | 0.127 | 9.33 × 10−4 | 0.084 | 0.030 | −1.444 | 0.0001 | −1.062 | 0.004 |
19 | 12:55561243 | intron ENSSSCG 00000044652 |
T | 0.106 | −0.034 | 0.079 | −0.012 | 0.523 | 0.376 | 0.036 | 0.193 | 0.285 |
1 Physical map position of SNP markers in the 749.1 kb critical region in SSC12; 2 reference allele; 3 LD correlation between the key SNP marker (shaded with grey color; the SNP at 12:54956054) and corresponding SNP markers; 4 regression coefficients computed from single-marker analysis; 5 p-values computed from single-marker analysis; 6 regression coefficients calculated from conditional analysis; 7 p-values calculated from conditional analysis; bold characters represent SNP markers showing extremely high LD correlation with the key SNP marker; † absence of regression coefficients and significance due to collinearity originated from extremely high LD with the key SNP marker. * We did not calculate the LD correlation because r is the correlation between the key SNP and other SNPs; ** We did not compute the β and p-value of the key SNP marker in the conditional analysis.