Table 5.
PUFA | P/S Ratio | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Single-Marker Analysis | Conditional Analysis | Single-Marker Analysis | Conditional Analysis | |||||||||
No | 1 BP | SNP annotation | 2 Allele 1 | 3 r | 4 b | 5p-value | 6 β | 7p-value | 4 b | 5p-value | 6 β | 7p-value |
1 | 12:54812172 | intron-GAS7 | T | −0.443 | 0.122 | 1.16 × 10−12 | 0.033 | 0.056 | 0.040 | 1.64 × 10−9 | 0.008 | 0.230 |
2 | 12:54842795 | intron-GAS7 | T | 0.390 | −0.066 | 0.0007 | 0.022 | 0.262 | −0.020 | 0.0090 | 0.013 | 0.089 |
3 | 12:54901488 | intron-GAS7 | G | −0.382 | 0.056 | 0.0006 | −0.006 | 0.723 | 0.014 | 0.0275 | −0.009 | 0.160 |
4 | 12:54929793 | intron-GAS7 | G | 0.638 | 0.141 | 7.24 × 10−22 | 0.039 | 0.010 | 0.052 | 1.92 × 10−20 | 0.016 | 0.007 |
5 | 12:54956054 | intron-GAS7 | C | *- | −0.233 | 1.03 × 10−39 | **- | **- | −0.082 | 3.41 × 10−33 | **- | **- |
6 | 12:55073130 | coding-MYH13 | A | −0.581 | 0.127 | 1.08 × 10−13 | 0.005 | 0.769 | 0.042 | 5.65 × 10−10 | −0.003 | 0.691 |
7 | 12:55093697 | intron MYH13 | A | −0.354 | 0.043 | 0.022 | −0.027 | 0.153 | 0.010 | 0.157 | −0.016 | 0.035 |
8 | 12:55120479 | 3′UTR MYH8 | G | −0.548 | 0.112 | 1.58 × 10−11 | 0.004 | 0.795 | 0.042 | 1.11 × 10−10 | 0.002 | 0.743 |
9 | 12:55180513 | 3′UTR MYH4 | G | −0.556 | 0.113 | 3.81 × 10−12 | 0.007 | 0.665 | 0.041 | 8.68 × 10−11 | 0.002 | 0.712 |
10 | 12:55229376 | exon MYH2 | G | 0.996 | −0.222 | 6.45 × 10−37 | † NA | † NA | −0.078 | 1.89 × 10−30 | † NA | † NA |
11 | 12:55262653 | exon MYH2 | T | 0.996 | −0.231 | 4.27 × 10−39 | † NA | † NA | −0.080 | 3.13 × 10−32 | † NA | † NA |
12 | 12:55351879 | intron MYH3 | A | 0.702 | 0.163 | 1.18 × 10−22 | 0.015 | 0.376 | 0.060 | 3.49 × 10−20 | 0.007 | 0.287 |
13 | 12:55373617 | 5′UTR MYH3 | G | 0.866 | −0.215 | 3.23 × 10−32 | −0.024 | 0.225 | −0.075 | 1.58 × 10−26 | −0.008 | 0.280 |
14 | 12:55373707 | 5′UTR MYH3 | 2 | 0.999 | −0.230 | 4.66 × 10−39 | † NA | † NA | −0.081 | 1.07 × 10−32 | † NA | † NA |
15 | 12:55447604 | intron ADPRM | G | 0.626 | −0.166 | 2.98 × 10−13 | −0.004 | 0.877 | −0.060 | 1.21 × 10−11 | −0.0003 | 0.972 |
16 | 12:55463919 | intron ADPRM | G | 0.946 | −0.224 | 7.37 × 10−37 | −0.008 | 0.667 | −0.080 | 9.11 × 10−32 | −0.004 | 0.548 |
17 | 12:55475542 | intron ADPRM | T | −0.630 | 0.139 | 9.59 × 10−21 | 0.036 | 0.018 | 0.051 | 2.38 × 10−19 | 0.015 | 0.013 |
18 | 12:55530321 | intron ENSSSCG 00000044652 |
A | −0.101 | 0.082 | 6.51 × 10−3 | 0.049 | 0.108 | 0.035 | 0.0036 | 0.022 | 0.066 |
19 | 12:55561243 | intron ENSSSCG 00000044652 |
T | 0.106 | −0.021 | 0.167 | −0.004 | 0.779 | −0.008 | 0.160 | −0.002 | 0.716 |
1 Physical map position of SNP markers in the 749.1 kb critical region in SSC12; 2 reference allele; 3 LD correlation between the key SNP marker (shaded with grey color; the SNP at 12:54956054) and corresponding SNP marker; 4 regression coefficients computed from single-marker analysis; 5 p-values computed from single-marker analysis; 6 Regression coefficients calculated from conditional analysis; 7 p-values calculated from conditional analysis; bold characters represent SNP markers showing extremely high LD correlation with the key SNP marker. † Absence of regression coefficients and significance due to collinearity originated from extremely high LD with the key SNP marker. * We did not calculate the LD correlation because r is the correlation between the key SNP and other SNPs; ** We did not compute the 𝛃 and p-value of the key SNP marker in the conditional analysis.