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. 2021 Aug 26;12(9):1323. doi: 10.3390/genes12091323

Table 5.

Results of conditional association analyses for PUFA and P/S ratio using SNP markers in the 749.1 kb critical region in SSC12.

PUFA P/S Ratio
Single-Marker Analysis Conditional Analysis Single-Marker Analysis Conditional Analysis
No 1 BP SNP annotation 2 Allele 1 3 r 4 b 5p-value 6 β 7p-value 4 b 5p-value 6 β 7p-value
1 12:54812172 intron-GAS7 T −0.443 0.122 1.16 × 1012 0.033 0.056 0.040 1.64 × 109 0.008 0.230
2 12:54842795 intron-GAS7 T 0.390 −0.066 0.0007 0.022 0.262 −0.020 0.0090 0.013 0.089
3 12:54901488 intron-GAS7 G −0.382 0.056 0.0006 −0.006 0.723 0.014 0.0275 −0.009 0.160
4 12:54929793 intron-GAS7 G 0.638 0.141 7.24 × 1022 0.039 0.010 0.052 1.92 × 1020 0.016 0.007
5 12:54956054 intron-GAS7 C *- −0.233 1.03 × 1039 **- **- −0.082 3.41 × 1033 **- **-
6 12:55073130 coding-MYH13 A −0.581 0.127 1.08 × 1013 0.005 0.769 0.042 5.65 × 1010 −0.003 0.691
7 12:55093697 intron MYH13 A −0.354 0.043 0.022 −0.027 0.153 0.010 0.157 −0.016 0.035
8 12:55120479 3′UTR MYH8 G −0.548 0.112 1.58 × 1011 0.004 0.795 0.042 1.11 × 1010 0.002 0.743
9 12:55180513 3′UTR MYH4 G −0.556 0.113 3.81 × 1012 0.007 0.665 0.041 8.68 × 1011 0.002 0.712
10 12:55229376 exon MYH2 G 0.996 −0.222 6.45 × 1037 NA NA −0.078 1.89 × 1030 NA NA
11 12:55262653 exon MYH2 T 0.996 −0.231 4.27 × 1039 NA NA −0.080 3.13 × 1032 NA NA
12 12:55351879 intron MYH3 A 0.702 0.163 1.18 × 1022 0.015 0.376 0.060 3.49 × 1020 0.007 0.287
13 12:55373617 5′UTR MYH3 G 0.866 −0.215 3.23 × 1032 −0.024 0.225 −0.075 1.58 × 1026 −0.008 0.280
14 12:55373707 5′UTR MYH3 2 0.999 −0.230 4.66 × 1039 NA NA −0.081 1.07 × 1032 NA NA
15 12:55447604 intron ADPRM G 0.626 −0.166 2.98 × 1013 −0.004 0.877 −0.060 1.21 × 1011 −0.0003 0.972
16 12:55463919 intron ADPRM G 0.946 −0.224 7.37 × 1037 −0.008 0.667 −0.080 9.11 × 1032 −0.004 0.548
17 12:55475542 intron ADPRM T −0.630 0.139 9.59 × 1021 0.036 0.018 0.051 2.38 × 1019 0.015 0.013
18 12:55530321 intron
ENSSSCG
00000044652
A −0.101 0.082 6.51 × 103 0.049 0.108 0.035 0.0036 0.022 0.066
19 12:55561243 intron
ENSSSCG
00000044652
T 0.106 −0.021 0.167 −0.004 0.779 −0.008 0.160 −0.002 0.716

1 Physical map position of SNP markers in the 749.1 kb critical region in SSC12; 2 reference allele; 3 LD correlation between the key SNP marker (shaded with grey color; the SNP at 12:54956054) and corresponding SNP marker; 4 regression coefficients computed from single-marker analysis; 5 p-values computed from single-marker analysis; 6 Regression coefficients calculated from conditional analysis; 7 p-values calculated from conditional analysis; bold characters represent SNP markers showing extremely high LD correlation with the key SNP marker. Absence of regression coefficients and significance due to collinearity originated from extremely high LD with the key SNP marker. * We did not calculate the LD correlation because r is the correlation between the key SNP and other SNPs; ** We did not compute the 𝛃 and p-value of the key SNP marker in the conditional analysis.