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. 2021 Sep 17;12(9):1437. doi: 10.3390/genes12091437

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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G0S2 is the most significant and positive correlated protein with the extrinsic apoptotic signaling pathway in metformin-treated macrophages. (A) Enrichment plot of the extrinsic apoptotic signaling pathway in the data set, including the ES score and positions of GeneSet members on the rank-ordered list. (B) Heat map of the analyzed GeneSet in the extrinsic apoptotic signaling pathway. (C) Heat map of top five pathways clustered leading edge subsets. Rows are gene sets and columns are genes. This matrix is clustered.