Figure 1.

Effects of melatonin (Mel) on SCC-15 cells viability, invasion and migration. SCC-15 cells were treated with different concertation of Mel (0, 0.5, 1, 2, 5 mM) for 24 h and 48 h. (A): Cell viability tested by CCK-8. (B,D): SCC-15 cells were treated with or without 2 mM melatonin, the invasion and migration ability of cell was determined by trasnwell migration assays at 24 h (B), transwell invasion assays at 36 h (B) and wound healing at 12 h, 24 h (D). (C,E): Quantitative data from three independent experiments are shown in the right panels, respectively (*** p < 0.001). Scale bars: (B,D), 100 nm.