Figure 2.

Identification of pivalate-regulated transcripts in the liver of pigs. (A): Volcano plot showing the differentially regulated hepatic transcripts between 5-week-old pigs orally administered either vehicle (group CON) or pivalate (group PIV) for 28 days. The double filtering criteria are indicated by horizontal (p-value < 0.05) and vertical (FC: > log₂(1.2) or <log₂(−1.2)) dashed lines. Transcripts in the upper left and the upper right corner represent the downregulated and the upregulated transcripts, respectively. The top 10 up- and downregulated transcripts with log₂(FC) and p-value are shown in tabular form. (B,C): Enriched gene ontology (GO) biological process (B) and molecular function (C) terms assigned to the genes that were differentially regulated between group PIV and group CON. GO terms are sorted by their enrichment p-values (EASE score) (top: lowest p-value; bottom: highest p-value). The number of genes is shown next to the bars.