Table 3.
Partial correlation between baseline network connectivity and cognitive changes controlling for age and gender, and Fisher’s Z transformation.
| ADAS-Cog Change a | |||||
|---|---|---|---|---|---|
| CST Group (n = 16) | TAU Group (n = 13) | Comparison of Fisher’s-Z, z (p) | |||
| r | Fisher’s-Z | r | Fisher’s-Z | ||
| Work, years | 0.75 ** | 0.97 | 0.20 | 0.20 | 1.83 (p = 0.06) |
| Baseline TBV/TICV | 0.42 | 0.45 | 0.66 * | 0.79 | 0.82 (p = 0.41) |
| Baseline DMN rs-FC, r | -0.41 | -0.44 | 0.12 | 0.12 | 1.32 (p = 0.19) |
| Baseline CEN rs-FC, r | 0.13 | 0.13 | 0.58 | 0.66 | 1.26 (p = 0.21) |
| Baseline LAN rs-FC, r | 0.27 | 0.27 | 0.25 | 0.26 | 0.05 (p = 0.96) |
TBV = total brain volume; TICV = total intracranial volume; DMN = default mode network; CEN = central executive network; LAN = language network; rs-FC = resting-state functional connectivity a Positive values signify improvement on ADAS-Cog. * p < 0.05; ** p < 0.01.