Figure 1.

Monoacylglycerol lipase (MAGL), an enzyme with central role in a complex biological network, regulating cannabinoid signaling and arachidonic acid metabolism. Legend: FA-fatty acids; AA-arachidonic acid; COX—cyclooxygenase; LOX—lipoxygenase; MAGs—monoacylglycerols (n = 8–18); 2-AG—2-arachidonoylglycerol; PG—prostaglandin; PGE2—prostaglandin E2; MAGK—monoacylglycerol kinase; eCBs—endocannabinoids; TRPV-1—transient receptor potential vanilloid type 1; CB1R—cannabinoid receptors 1; CB2R—cannabinoid receptors 2; Ca_v3 T-type calcium channel; A3R—adenosine receptor 3; GABA-A receptors- γ-Aminobutyric acid type A receptors; PPAR-γ receptors—Peroxisome proliferator-activated γ receptors; GPR55—G protein-coupled receptor 55.