Figure 8.

Long-term administration of C646 pharmacological inhibitor of p300/CBP prevents glomerular hypertrophy in diabetic mice. (A) Quantification of the relative glomerular area in each experimental animal group. (B) Representative hematoxylin-eosin phase-contrast microscopy images taken at 40× magnification depicting the staining of glomeruli. Note that C646 treatment of diabetic mice reduced significantly the relative glomerular hypertrophy to the level of control non-diabetic mice. n = 23/condition quantified glomeruli, *** p < 0.001, p-values taken in relation to non-diabetic + vehicle condition; ## p < 0.01, p-values taken in relation to diabetic + vehicle condition.