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Estimated PK parameter of pazopanib with a mono compartmental model.
| Parameter | Value (RSE%) |
IIV (RSE%) |
IOV (RSE%) |
Covariate (RSE%) |
|---|---|---|---|---|
| ka (h−1) | 0.976 (12.3) | 0.211 (44.6) | ||
| V/F (L) | 22.3 (9.25) | 0.248 (46.9) | 0.384 (18) | ASAT: −0.838 (29) |
| Cl/F (L·h−1) | 0.458 (9.73) | 0.714 (13.3) | 0.371 (12.4) | |
| Constant residual error | 4.9 (8.07) | |||
| Proportional residual error | 0.05 (26.2) |
Note: inter-individual variability (IIV) is expressed in ω2.
