Table 7.
Association of PI3KR1 rs7713645 A > C gene variation with T2D.
| Mode of Inheritance |
Controls (n = 108) | Cases (n = 100) |
OR (95% CI) | RR (95% CI) | p-Value |
|---|---|---|---|---|---|
| Co-dominant model | |||||
| PIKR-AA | 37 | 8 | 1 (ref.) | 1 (ref.) | |
| PIKR-CA | 60 | 80 | 6.16 (2.67 to 14.20) | 1.91 (1.51 to 2.42) |
0.0001 |
| PIKR-CC | 11 | 12 | 5.04 (1.64 to 15.45) | 1.71 (1.09 to 2.69) |
0.0046 |
| Dominant model | |||||
| PIKR-AA | 37 | 8 | 1 (ref.) | 1 (ref.) | |
| PIKR-(CA + CC) | 71 | 92 | 5.99 (2.62–13.66) | 1.88 (1.51–2.35) | 0.0001 |
| Recessive model | |||||
| PIKR-(AA + CA) | 97 | 88 | 1 (ref.) | 1 (ref.) | |
| PIKR-CC | 11 | 12 | 1.20 (0.50–2.86) | 1.09 (0.70–1.71) | 0.67 |
| Allele | |||||
| PIKR-A | 134 | 96 | 1 (ref.) | 1 (ref.) | |
| PIKR-C | 82 | 104 | 1.77 (1.19–2.61) | 1.32 (1.08–1.60) | 0.004 |
Abbreviations: OR = Odds Ratio, RR = Risk Ratio, CI = Confidence interval; Statistically significant p-values (p < 0.05) were indicated with bold numbers.