Table 4.
Univariate analysis of the EMT-TF expressions and clinicopathological features of over 350 PTC patients from the TGCA database. In parentheses is the number of patients. TDS, Thyroid Differentiation Score. Median values of the mRNA Z-scores in PTC tissues are listed for each category of clinical parameters, except the patient’s age and TDS, for which correlation coefficients are reported.
| Twist1 | p | Snai1 | p | Snai2 | p | Zeb1 | p | Zeb2 | p | |
|---|---|---|---|---|---|---|---|---|---|---|
| Gender | ||||||||||
| Male (n = 93) Female (n = 271) |
−0.326 −0.329 |
0.07 | −0.305 −0.235 |
0.41 | −0.153 −0.278 |
0.04 | −0.105 −0.168 |
0.69 | −0.132 −0.257 |
0.26 |
| Age (year) Corr. Coeff. | 0.016 | 0.76 | −0.054 | 0.30 | 0.066 | 0.21 | −0.016 | 0.76 | −0.016 | 0.76 |
| Histological variants | ||||||||||
| Classical (n = 249) Follicular (n = 81) Tall cell (n = 28) |
−0.320 −0.401 0.099 |
<0.001 | −0.219 −0.285 −0.311 |
0.56 |
−0.226 −0.426 −0.106 |
0.02 | −0.206 0.273 −0.682 |
0.001 | −0.209 −0.269 −0.127 |
0.68 |
| BRAF/RAS status | ||||||||||
| BRAF-like (n = 272) RAS-like (n = 116) |
−0.239 −0.441 |
<0.001 | −0.278 −0.179 |
0.12 | −0.163 −0.441 |
<0.001 | −0.209 0.205 |
<0.001 | −0.155 −0.310 |
0.08 |
| TDS Corr. Coeff. | −0.245 | <0.001 | 0.245 | <0.001 | −0.071 | 0.16 | 0.327 | <0.001 | 0.046 | 0.37 |
| pT | ||||||||||
| T1–2 (n = 231) T3–4 (n = 131) |
−0.359 −0.242 |
<0.01 | −0.231 −0.309 |
0.36 | −0.306 −0.153 |
0.40 | −0.045 −0.313 |
0.02 | −0.230 −0.282 |
0.33 |
| pN | ||||||||||
| N0 (n = 172) N1 (n = 153) |
−0.357 −0.239 |
<0.01 | −0.289 −0.221 |
0.44 | −0.338 −0.138 |
0.02 | −0.086 −0.164 |
0.81 | −0.199 −0.240 |
0.83 |
| TNM Stage | ||||||||||
| I–II (n = 231) III–IV (n = 131) |
−0.350 −0.261 |
<0.01 | −0.232 −0.315 |
0.19 | −0.299 −0.129 |
0.28 | −0.095 −0.307 |
0.05 | −0.233 −0.252 |
0.43 |
| Recurrences | ||||||||||
| No (n = 301) Yes (n = 22) |
−0.311 −0.394 |
0.48 | −0.288 −0.337 |
0.68 | −0.207 −0.500 |
0.07 | −0.142 −0.548 |
0.02 | −0.230 −0.377 |
0.40 |