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. 2021 Sep 17;10(9):1484. doi: 10.3390/antiox10091484

Figure 2.

Figure 2

Impact of CIH on (A) kidney weight, (B) kidney histology, and (C) uACR. (A) No differences were found in the ratio of kidney weight to body weight (n = 6 for Nx35D; n = 8 for CIH35D). (B) No relevant histological changes were observed for the left kidney of all groups (n = 3 animals per group). Staining was performed in 10% formaldehyde-fixed paraffin-embedded left kidney sections using H&E; Magnification: 10×; (C) CIH increases uACR. Number of animals per group: Day of study (n for Nx; n for CIH): D1 (8; 4), D7 (4; 4) D14 (4; 2) D21 (6; 8); D35 (6; 8); D60 (9; 7). Multiple t-test; comparison Nx vs. CIH: * p < 0.05; ** p < 0.01. CIH: chronic intermittent hypoxia; Nx: normoxic; uACR: urinary albumin-to-creatinine ratio.