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. 2021 Sep 17;10(9):1484. doi: 10.3390/antiox10091484

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Impact of IH chronicity cysteine related thiolome in kidney cortex. (A) Total glutathione; (B) Cysteinylated proteins; (C) Cysteinylglycinylated proteins; (D) free oxidized Cys to reduced Cys ratio; (E) free oxidized Cys to Cysteinylated proteins ratio. Nx7D was used as control for CIH1D and CIH7D. Number of animals per group: Day of study (n for Nx; n for CIH): D1 (5;5), D7 (5; 5) D14 (5; 6) D21 (11; 6), D35 (6; 8) and D60 (6; 6). Multiple t-test; comparison Nx vs. CIH: * p < 0.05; ** p < 0.01; *** p < 0.001. CIH: chronic intermittent hypoxia; Cys: cysteine; CysGly: cysteinylglycine; CysGlySP: cysteinylglycinylated proteins; CysSH: reduced cysteine; CysSSP: cysteinylated proteins; GSH: glutathione; Nx: normoxia; oxCys: oxidized cysteine.