Figure 2.

Proposed cancer vaccination strategies in the consolidation setting following standard-of-care chemotherapy and surgery in OC. The preclinical murine ID8 ovarian tumor model can serve as a useful tool to mimic the actual OC clinical scenario described here for evaluating combinatorial OC standard-of-care treatments and cancer vaccination strategies. As an example, during the first-line debulking surgery, different clinical samples (i.e., tumors, ascites and blood) can be obtained from the patients for preparing tumor WTL, DC vaccine, identifying and validating tumor (neo)-antigens from TILs and tumor cells. Next, different cancer vaccination strategies as described in Figure 1 can be implemented in combination with the OC standard-of-care, maintenance therapy or follow-up. Finally, additional blood and ascites samples can be obtained from the patients to evaluate their therapeutic anti-tumor T cell responses as well as track their disease regressions.