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Plasma concentration of edaravone after administration of edaravone or TEJ-1704 to rats. (A) IV administration of edaravone 3 mg/kg (○, dotted line) and TEJ-1704 19.8 mg/kg (●, solid line). (B) PO administration of edaravone 30 mg/kg (○, dotted line) and TEJ-1704 99 mg/kg (●, solid line), 198 mg/kg (□, solid line), and 660 mg/kg (▼, solid line).
