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Plasma concentration of edaravone after administration of edaravone or TEJ-1704 to beagle dogs. (A) IV infusion of edaravone 1 mg/kg (○, dotted line) and IV bolus of TEJ-1704 3.3 mg/kg (●, solid line). (B) PO administration of edaravone 3 mg/kg (○, dotted line) and TEJ-1704 9.9 mg/kg (●, solid line), 19.8 mg/kg (□, solid line), and 39.6 mg/kg (▼, solid line).
