Table 1.

The pharmacokinetic study design using Sprague Dawley rats.

Group	Drug	Route	n	Dose (mg/kg)	Edaravone Equivalent Dose (mg/kg)	Blood Sampling Time	Organ Collection
R1	Edaravone	IV	5	3	3	0, 2, 5, 10, 15, 25, 40 min 1, 2, 4, 6, 10 h	-
R2	Edaravone	PO	5	30	30		-
R3	TEJ-1704	IV	5	19.8	6		-
R4	TEJ-1704	PO	5	99	30		10 h
R5	TEJ-1704	PO	5	198	60		10 h
R6	TEJ-1704	PO	5	660	200		10 h
R7	TEJ-1704	PO	18	99	30	-	15, 30, 45 min 1, 2, 4 h
R8	TEJ-1704	PO	18	198	60	-
R9	TEJ-1704	PO	18	660	200	-