Table 2.

The pharmacokinetic study design using beagle dogs (n = 5).

Group	Drug	Route	Dose (mg/kg)	Edaravone Equivalent Dose (mg/kg)	Sampling Time
B1	Edaravone	IV infusion (1 h)	1	1	Blood: 0, 2, 5, 10, 15, 25, 40 min, 1, 2, 4, 6, 10 h CSF: 15, 30 min, 1, 4, 24 h Urine/Feces (B3–B6): 0–2, 2–6, 6–12, 12–24 h
B2	Edaravone	PO	3	3
B3	TEJ-1704	IV bolus	3.3	1
B4	TEJ-1704	PO	9.9	3
B5	TEJ-1704	PO	19.8	6
B6	TEJ-1704	PO	39.6	12