Table 3.

Calibration information of edaravone in rat and beagle dog matrices (n = 5).

Matrix	Linear Regression Equation *	r2
Rats
Plasma	y = (0.016 ± 0.001) + (0.002 ± 0.003)	0.998 ± 0.001
Brain	y = (0.020 ± 0.02) + (0.006 ± 0.003)	0.996 ± 0.003
Liver	y = (0.020 ± 0.001) + (0.046 ± 0.008)	0.999 ± 0.001
Kidney	y = (0.019 ± 0.001) + (0.043 ± 0.024)	0.998 ± 0.001
Heart	y = (0.019 ± 0.001) + (0.013 ± 0.003)	0.996 ± 0.005
Lung	y = (0.020 ± 0.01) + (0.056 ± 0.019)	0.997 ± 0.002
Gastro-intestinal (GI) tract	y = (0.020 ± 0.01) + (0.026 ± 0.005)	0.997 ± 0.002
Beagle dogs
Plasma	y= (0.023 ± 0.001) + (0.009 ± 0.008)	0.998 ± 0.002
Cerebrospinal fluid (CSF)	y= (0.023 ± 0.001) + (0.002 ± 0.001)	0.999 ± 0.001
Urine	y= (0.016 ± 0.001) − (0.063 ± 0.021)	0.991 ± 0.0004
Feces	y= (0.022 ± 0.001) − (0.155 ± 0.252)	0.995 ± 0.001

* In linear regression equations, y is the peak-area ratio of analytes to IS and x (ng/mL) is the plasma concentration of analyte.