Table 5.
Summary of the edaravone plasma PK parameters in rats and beagle dogs.
| Group | Route | Half-Life [15] | Tmax [15] | C0 (ng/mL) | Cmax (ng/mL) | AUClast (ng·h/mL) |
|---|---|---|---|---|---|---|
| Rats | ||||||
| R1 | IV | 1.8 ± 0.1 | - | 8398.7 ± 1543.1 | - | 6204.1 ± 1026.0 |
| R2 | PO | 1.7 ± 0.2 | 0.4 ± 0.1 | - | 35,420.4 ± 4878.3 | 46,667.0 ± 12,543.6 |
| R3 | IV | 1.8 ± 0.2 | 0.04 ± 0.02 | 2960.4 ± 808.2 | 6948.4 ± 1499.9 | |
| R4 | PO | 12.9 ± 4.8 | 0.7 ± 0.3 | - | 3285.6 ± 456.9 | 16,016.7 ± 3436.1 |
| R5 | PO | 15.0 ± 8.4 | 0.8 ± 0.2 | - | 3866.6 ± 427.1 | 20,497.9 ± 6365.7 |
| R6 | PO | 16.5 ± 11.5 | 0.9 ± 0.7 | - | 5680.5 ± 850.7 | 38,596.6 ± 11,716.4 |
| Beagle dogs | ||||||
| B1 | IV | 4.1 ± 0.5 | - | - | 1589.6 ± 415.0 | 3120.1 ± 1041.1 |
| B2 | PO | 3.6 ± 0.4 | 0.2 ± 0.1 | - | 7840.7 ± 1144.4 | 7284.6 ± 1641.1 |
| B3 | IV | 4.0 ± 0.3 | 0.3 ± 0.2 | - | 663.6 ± 154.4 | 3014.7 ± 1142.6 |
| B4 | PO | 5.9 ± 1.1 | 1.8 ± 0.4 | - | 665.2 ± 125.0 | 4686.4 ± 2092.4 |
| B5 | PO | 5.4 ± 1.6 | 1.6 ± 0.5 | - | 712.9 ± 101.2 | 7258.9 ± 1727.6 |
| B6 | PO | 6.2 ± 1.4 | 1.3 ± 0.7 | - | 809.2 ± 169.3 | 9953.7 ± 2135.0 |