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Summary of edaravone CSF PK parameters in beagle dogs.
| Group | Tmax [15] | Cmax (ng/mL) | AUC0–24h (ng·h/mL) |
|---|---|---|---|
| B1 | 1.0 ± 0.0 | 51.7 ± 9.2 | 121.4 ± 19.5 |
| B2 | 0.4 ± 0.1 | 23.5 ± 7.1 | 53.4 ± 9.9 |
| B3 | 0.3 ± 0.0 | 6.4 ± 2.8 | 29.1 ± 11.0 |
| B4 | 2.2 ± 1.6 | 4.9 ± 2.0 | 48.0 ± 8.0 |
| B5 | 0.8 ± 0.3 | 6.4 ± 1.5 | 56.8 ± 11.0 |
| B6 | 1.6 ± 1.6 | 5.6 ± 1.1 | 66.9 ± 9.7 |
