Table 2.
Summary of neutrophil gene expression reported in major diseases. Genes featured are restricted to those highlighted by the original authors and/or the largest fold change reported by the study. Bold indicates common to the studies cited, underlined indicates common to multiple diseases. RNAseqRNA sequencing; NETosis—neutrophil extracellular trap formation.
| Disease | Analysis Methods | Neutrophil Gene Expression Observed | Citations |
|---|---|---|---|
| Bacterial/Fungal infection | RNAseq | Cxcl9, Gbp5, Ifit2, Cxcl11, Ifi205, Il1a, Ikbke, Csf3, Cxcl10, Ifnar1, Ifnar2, Tlr9, Il12a, Mx2, Ccl4, Il10, Nlrc5, Il1f6, Gbp3, Tnfrsf9, Phynin1, IL15ra, IL6, Ccl2, Tnf, Nos2, Cln3, Zfp64, Fundc2, Brix1, Slfn3, Yipf6, Dlg1, Smek1, Prr12, 2410016O06Rik, Ebna1bp2, Cdc37l1, Impa1, Gclc, Atp2c1, Las1l, Ahi1, Zfp192, Nt5e, Piga | [69,70] |
| Viral Infection | RNAseq, scRNAseq | IFNβ1, ISG15, IRF1, CXCL10, CASP4, NOD1, PARP14, EIF2AK2, XAF1, PARP9, PARP10, BCL6, Krt18, Prf1, IFITM1/3, RSAD2, CD274 (PD-L1), ZC3H12A, CD177, ARG1, S100A8, S100A9, CXCR4, SELL, SPI1 | [71,72,73] |
| Chronic Inflammation/Auto-immune | RNAseq | PAM , ADARB2, C5orf56, ICAM1, IL1B, CCR1, IFIH1, SOCS1, TNFAIP3, TNFSF13B, OAS1, OAS2, IFI35, IFI44, IFI44L, IFI6, IFIT2, IFIT3, IFIT5, IFITM1/3, APOBEC3B, AASS, ELF5, COL4A3, ZNF772, RNU5A-1, CEACAM19, OAS3, PGM5, TIAF1, LY6E, LILRB5, FAM21B, TBC1D15, HMGN3, PRKAR2B, PLXNB2, APMAP, PGM1, ACAP1, PYGL, S100A12, SRPK1, ACSL1, CLEC4D, MAP4K4, MAPK14, ACTB, PXK, TP53I11, ZDHHC3, BMX, PGD, SLC37A3, SLC26A8, ALOX5, KIF1B, PLP2, S100A9 | [74,75,76] |
| Cancer | Microarray, RNAseq, scRNAseq | CD206, CCL2, ARG2, Nos2, CALR, LGMN, CXCL13, CXCL10, TNF, CASS4, CTSC, CCL3, CD274 (PD-L1), TLR1, TLR4, IRAK2, IEX1, SOD2, GADD45b, BCL2A1, CD74, Cd1d-1, Psme1, H2-DMa, DMb1, Eb1, CCL17, CXCL9, CXCL16, CXCL1, CXCL2, IL1a, IL1b, IL12 | [77,78,79,80,81] |
| Cystic Fibrosis | RNAseq, scRNAseq | FAM107A, SPOCK2, GZMH, GPRC5B, EDG1, TMEM35, A_24_P920715, AGT, ACVR1C, HBS1L, TRBV5-4, HBA2, PKN1, AEBP1, EPB41L2, GFAP, HBB, RNASEN, AK090499, HBA1, CXCR4, CD83, IRAK2, IRAK3, TRAF3, PLAU, CREM, HES4, KRAS, TRPM7, CCL3, CCL4, TLR2, IGF2R, KLRG1, CCR5, C4A, CCR4, CFD, SPP1, IFITM2, MSH2, FCGR2C, TREM1, CFD, CDKN1A, PLK3, ZC3HC1, MSH2, CYP26B1, KIF20B, CENPV, G0S2, CDK6, AHR, MYH6, PPP4R4, AIM2, NLRP3, S100A12 | [59,61,74,82] |