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Schematic representation of the kynurenine metabolic pathway. Abbreviations: FAM—N-formylkynurenine formamidase; IDO1—indoleamine 2,3-dioxygenase 1; IDO2—indoleamine 2,3-dioxygenase 2; TDO—tryptophan 2,3-dioxygenase; KMO—kynurenine 3-monooxygenase; 3-HAAO—3-hydroxyanthranilate 3,4-dioxygenase; ACMSD—2-aminomuconic acid semialdehyde dehydrogenase; QPRT—quinolinic acid phosphoribosyltransferase.
