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. 2021 Aug 30;10(9):2246. doi: 10.3390/cells10092246

Figure 2.

Figure 2

Plectin mutation analysis and expression across several cancers. (A) Plectin mutations from cBioPortal based on TCGA pan-cancer datasets (accessed 17 July 2021) [56,57]. (B) Oncoprint plot from cBioPortal demonstrating plectin is altered in 11% (1158/10,950) of all TCGA pan-cancer atlas studies. (C) The alteration frequency of plectin across different cancers from TCGA pan-cancer datasets using cBioPortal. (D) Plectin’s gene expression in tumor and normal tissue using the TNMPlot portal (accessed on 22 July 2021), which mines data from GEO, GTEx, TCGA, and TARGET databases [29]. N = normal tissue, T = tumor tissue, sample size of the cohort is specified below, * p-value < 0.01; ** p-value < 0.001; analyzed by Mann-Whitney U-test. Abbreviations, GEO: Gene Expression Omnibus, GTEx: Genotype-Tissue Expression, TARGET: Therapeutically Applicable Research to Generate Effective Treatments, TCGA: The Cancer Genome Atlas.