Figure 5.

Plectin has been widely leveraged to enhance the specificity of imaging agents and the efficacy of therapeutic modalities. Plectin-targeting peptides (PTPs) or anti-plectin antibodies have been shown to increase the accumulation of nanoparticles (NPs), microbubbles, and imaging probes to PDAC cells and tumors. Similarly, PTPs have increased the drug payload of different drug delivery systems (e.g., liposomes, NPs, AAV) across various cancer models. Recent studies have revealed the anti-cancer effects of direct therapeutic targeting of plectin with metallodrugs in colon cancer and a monoclonal antibody in ovarian cancer, opening the door to a new class of plectin targeted therapy.