Table 1.

Plectin and its interacting partners regulate invasion and migration.

Protein Name	Cancer Type	Function of Protein	Effect of Interaction	Reference
Dlc1	Ovarian cancer	Tumor suppressor gene encoding a GTPase-activating protein	Plectin binds to transcriptional isoforms of Dlc1. Loss of Dlc1 increased focal adhesions and stress fiber formation.	[70]
KPNA2	Lung cancer	Imports proteins to the nucleus	An increase in complex formation is seen in lung adenocarcinoma cells with higher metastatic potential.	[86]
Periplakin	Breast cancer	Cytolinker plakin protein	Plectin isoforms plectin-1f and -1k interact with the N-terminus of periplakin at cell borders.	[69]
RON	Pancreatic cancer	Receptor tyrosine kinase	Upon binding its ligand, RON translocates to the cell surface and interacts with plectin at lamellipodia, disrupting the plectin–integrin β4 interaction via phosphorylation of PI3K, thus increasing cancer cell migration.	[68]
SNRPA1	Breast cancer	Mediator of alternative splicing	Exon 31 of plectin was identified as a SNRPA1 target, resulting in a rod domain-containing isoform that is upregulated in metastatic breast cancer tumors. Ablation of this plectin SNRPA1-mediated isoform resulted in reduced invasion and metastatic capacity.	[67]

Dlc1: deleted in liver cancer 1; KPNA2: karyopherin alpha; RON: recepteur d’origine nantais; SNRPA1: small nuclear ribonucleoprotein polypeptide.