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. 2021 Sep 13;11(9):1354. doi: 10.3390/biom11091354

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Line charts with biomarkers’ changes according to baseline values for S100A8/A9. (A) * p < 0.001 vs. baseline, ** p < 0.01 vs. baseline, ^a p < 0.001 vs. 1st, 2nd and 3rd quartile, ^b p < 0.001 vs. 1st quartile, ^c p < 0.01 vs. 1st quartile; sRAGE (B) * p < 0.001 vs. baseline, ^a p< 0.001 vs.1st quartile; IL-6 (C) * p < 0.001 vs. baseline,** p < 0.05 vs. baseline, ^a p < 0.001 vs. 3rd and 4th quartile, p < 0.05 vs. 2nd quartile, ^b p < 0.001 vs. 2nd quartile, p < 0.05 vs. 3rd quartile; IL-1β (D) * p < 0.001 vs. baseline, ^a p < 0.001 vs. 1st, 2nd and 3rd quartile.