Table 6.
Pharmacokinetic parameters of ginsenosides in mouse after single dosing RGE after repeated oral administration of amoxicillin with or without repeated LAB treatment.
| Ginsenosides | Amoxicillin | ||||
|---|---|---|---|---|---|
| AUC (ng/mL·h) | Cmax (ng/mL) | Tmax (h) | MRT (h) | Half-Life (h) | |
| GRb1 | 752.3 ± 477.6 | 23.7 ± 11.6 | 3.3 ± 1.2 | 18.6 ± 1.6 | 20.1 ± 2.2 |
| GRb2 | 385.9 ± 243.6 | 10.9 ± 5.2 | 4.0 ± 0.0 | 20.2 ± 1.7 | 19.2 ± 2.3 |
| GRc | 448.2 ± 268.1 | 13.2 ± 6.6 | 4.7 ± 3.1 | 20.6 ± 1.2 | 20.2 ± 1.8 |
| GRd | 213.1 ± 151.3 | 6.5 ± 5.1 | 5.3 ± 2.3 | 24.1 ± 3.9 | 29.2 ± 2.7 |
| CK | NC | NC | NC | NC | NC |
| PPD | NC | NC | NC | NC | NC |
| GRg3 | NC | NC | NC | NC | NC |
| PPT | NC | NC | NC | NC | NC |
| Ginsenosides | Amoxicillin + LAB | ||||
| AUC (ng/mL·h) | Cmax (ng/mL) | Tmax (h) | MRT (h) | Half-life (h) | |
| GRb1 | 622.1 ± 163.6 | 26.2 ± 4.6 | 4.7 ± 3.1 | 16.9 ± 1.0 | 16.2 ± 0.9 |
| GRb2 | 419.2 ± 108.6 | 15.1 ± 3.4 | 8.0 ± 0.0 | 18.1 ± 0.9 | 21.6 ± 1.7 |
| GRc | 524.4 ± 146.6 | 18.3 ± 4.3 | 8.0 ± 0.0 | 19.0 ± 1.3 | 24.1 ± 2.4 |
| GRd | 618.1 ± 385.6 * | 18.4 ± 6.9 * | 16.0 ± 9.2 | 20.6 ± 3.7 | 25.5 ± 3.8 |
| CK | 249.8 ± 103.0 | 9.3 ± 2.9 | 8.0 ± 0.0 | 13.7 ± 6.2 | 12.0 ± 5.0 |
| PPD | 1607.3 ± 463.7 | 73.0 ± 14.6 | 6.7 ± 2.3 | 16.0 ± 1.2 | 18.4 ± 2.2 |
| GRg3 | 25.3 ± 10.6 | 4.8 ± 1.9 | 2.5 ± 1.0 | 3.5 ± 0.9 | 5.3 ± 1.1 |
| PPT | 894.4 ± 161.3 | 63.4 ± 0.6 | 4.0 ± 0.0 | 13.7 ± 2.9 | 14.4 ± 3.0 |
AUC: area under the plasma concentration–time curve from 0 to 48 h; Cmax: maximum plasma concentration; Tmax: time to reach Cmax; MRT: mean residence time. NC: Not calculated. Data expressed as mean± standard deviation (n = 3). * p < 0.05 compared with control group.