Table 1.
Examples of RNF4 substrates. Upper table: Substrates that are recognized once SUMOylated.
| SUMO-Dependent Substrates of RNF4 | |
| Protein | References |
| PML | [114,115,116,136] |
| JARID1B | [137] |
| SP100 * | [138] |
| IFI16 | [139] |
| CFTR | [140] |
| Pea3 | [141] |
| BLM | [109] |
| FANCI, FANCD2 (ID complex) | [142] |
| PIAS1, PIAS2, PIAS3 | [143] |
| ZNF451 | [143] |
| NSMCE2 | [143] |
| Ubc9 | [143] |
| BRCA1–BARD1 complex | [143] |
| MDC1 | [144] |
| PARIS/ZNF746 | [145] |
| KAP1 | [104] |
| Rta | [146] |
| NDRG2 | [147] |
| Tax | [148] |
| Ataxin-7 | [149] |
| FXR | [150] |
| SUMO-independent substrates of RNF4 | |
| Protein | Reference |
| c-Myc | [97] |
| c-Jun | [97] |
| β-catenin | [97] |
| NICD | [97] |
| PGC1 α | [97] |
| eIF2α | [98] |
| HIF1α | [98] |
“*” indicates partial proof. Lower table: Substrates that are recognized by RNF4 independent of SUMOylation.