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. 2021 Sep 18;11(9):637. doi: 10.3390/metabo11090637

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Perturbation-based mathematical modeling of the autophagic sensor dynamics indicates cell-line specific modes of action of chemotherapeutic agents on the autophagic flux. (A) Qualitative changes in the autophagy sensor induced by chemotherapeutic drugs treatment, to emphasize the differences, only the images corresponding to 48 h post-treatment are shown. (B) Cell-line specific modes of action of chemotherapeutic agents on the autophagic flux. A simplified topology of the autophagic flux was used. The magnitude of the modulating effect for each drug proposed activity is proportional to the line width. AL: autophagolysosomes, AP: autophagosomes, CIS: cisplatin, CYT: cytoplasm, EPI: epirubicin, HCQ: hydroxychloroquine, PAC: paclitaxel RAP: rapamycin, SPA: Spautin-1, TOR: Torin-2, WRT: wortmannin.