Figure 1.

Amino acid sequence of globular and ribbon GID (A) and the three-dimensional NMR solution structure of gGID (PDB: 1MTQ) (B). γ: γ-carboxyglutamic acid, O: hydroxyproline; the connectivities of disulfide bonds are shown as orange lines and the disulfide bonds are shown as orange sticks in the 3D structure; “C” and “N” stand for the C-terminus and N-terminus, respectively. The two loops, which are defined as inter-Cys segments, are shown in green and blue, respectively, on the amino acid sequence and three-dimensional structure. In panel B, the globular GID three-dimensional structure is shown in two orientations differentiated by a 180° turn along the indicated axis.