Table 1.
Pediatric spinal tumors, location, and molecular data. * = the most common; / = no preferential location.
| Tumors | Location * | Molecolar/Genetics |
|---|---|---|
| LGG | Cervico and thoracic tract | KIAA1549–BRAF fusion or BRAFV600E mutation; NF1 mutation |
| HGG | / | H3K27M |
| DL-GNT | Leptomeningeal dissemination | KIAA1549–BRAF, NTRK1/2/3, or TRIM33:RAF1 fusion |
| Ependymomas | Cervical/lumbo-sacral tract | RELA-/YAP1- fusion; nMyc amplification NF2 mutation |
| Hemangioblastomas | Variable epicenter | VHL mutation |
| Mesenchymal chondrosarcomas | Thoracic tract | HEY1/NCOA2 fusion |
| Meningiomas | / | NF2 mutation; SMARCE1, SMARCB1, or SUFU mutation |
| Schwannomas | Nerve sheaths | NF2 mutation; LZTR1 or SMARCB1 mutation |
| Plexiform neurofibromas | Nerve sheaths | NF1 mutation |
| Atypical teratoid/rhabdoid tumor | / | SMARCB1 mutation |
| Embryonal tumor with multilayered rosettes | / | C19MC amplification |