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. 2021 Sep 15;13(9):1476. doi: 10.3390/pharmaceutics13091476

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) IMQ retention (mean ± SD, n ≥ 4) in the epidermis and dermis, red dots () represent IMQ concentration in the formulations applied. Data on Transcutol^® saturated solution is from [15]. (B) Delivery efficiency (% delivered after 5 h) of TO20 and semisolid formulations. (p * < 0.05); p-values obtained from t-test analysis for epidermis, dermis and total amount of the drug in the skin for all formulations tested are reported in Table S4.

Inline graphic — (A) IMQ retention (mean ± SD, n ≥ 4) in the epidermis and dermis, red dots () represent IMQ concentration in the formulations applied. Data on Transcutol^® saturated solution is from [15]. (B) Delivery efficiency (% delivered after 5 h) of TO20 and semisolid formulations. (p * < 0.05); p-values obtained from t-test analysis for epidermis, dermis and total amount of the drug in the skin for all formulations tested are reported in Table S4.