Table 2.
Composition of micellar solutions with their method of preparation and the correspondent code. Drug solubility, concentration of the co-solubilizing agent and pH of the formulations are also reported. Data are reported as mean ± SD, n ≥ 3.
| Code | Composition | Method | Imiquimod Solubility (µg/mL) | Fatty Acid Content (µg/mL) | pH |
|---|---|---|---|---|---|
| T20 | TPGS 20 mM | 1 | 1.70 ± 0.63 | - | 6.14 ± 0.14 |
| T40 | TPGS 40 mM | 1 | 109.81 ± 53.77 | - | 5.06 ± 0.45 |
| T100 | TPGS 100 mM | 1 | 188.76 ± 6.76 | - | 5.37 ± 0.43 |
| T200 | TPGS 200 mM | 1 | 231.51 ± 84.21 | - | - |
| TO20 | TPGS 20 mM + oleic acid | 1 | 1154.08 ± 112.78 | 3156.69 ± 882.31 | 4.79 ± 0.03 |
| TO40 | TPGS 40 mM + oleic acid | 1 | 1520.61 ± 72.98 | 7871.15 ± 808.39 | 4.69 ± 0.02 |
| TO100 | TPGS 100 mM + oleic acid | 1 | 2517.56 ± 70.26 | 20519 ± 956.79 | 4.92 ± 0.03 |
| TLN20 | TPGS 20 mM + linolenic acid | 1 | 912.59 ± 27.50 | 7898.09 ± 180.30 | 4.76 ± 0.06 |
| TL20 | TPGS 20 mM + linoleic acid | 1 | 731.77 ± 52.25 | 3998.00 ± 140.60 | 5.09 ± 0.04 |
| TI20 | TPGS 20 mM + isostearic acid | 1 | 393.24 ± 13.34 | n.d. a | 5.34 ± 0.01 |
| TP20 | TPGS 20 mM + Peceol™ | 1 | 180.21 ± 35.99 | - | 5.30 ± 0.10 |
| TPO20 | TPGS 20 mM + Plurol® Oleique | 1 | 126.55 ± 5.52 | - | 5.99 ± 1.00 |
| TSP20 | TPGS 20 mM + Span® 80 | 1 | 115.34 ± 76.82 | - | 6.20 ± 0.13 |
| TO20-2 | TPGS 20 mM + oleic acid | 2 | 1659.34 ± 109.87 | 8683.54 ± 344.36 | 4.63 ± 0.03 |
| TO20-3 | TPGS 20 mM + oleic acid | 3 | 304.76 ± 4.06 | n.d. | 3.44 ± 0.01 |
n.d. not determined; a not UV-absorber.