Table 3.
Summary of cellular consequences resulting from interactions between different USPs and target proteins associated with chromatin remodeling.
| USPs | Targets | Cell Model Association | Effects | Refs |
|---|---|---|---|---|
| USP7 | EZH2–PRC2 | DUI145 and PC3 cells (prostate adenocarcinoma) |
Overexpression of USP7 increases migration and invasion and inhibits apoptosis | [118] |
| PC3 cells (prostate adenocarcinoma; xenografts) |
USP7 knockdown inhibits tumoral growth in mice bearing tumor xenografts | |||
| USP11 | H2A, H2B | HeLa cells (cervical adenocarcinoma) |
USP11 knockdown induces apoptosis; USP11 knockdown reduces cell clonogenic survival in irradiated cells | [117] |
| USP16 | H2A | Hematopoietic stem cells (HSC) (bone marrow) # |
USP16 knockdown leads to an increase in cellular quiescence; USP16 regulates haematopoiesis and HSC functions | [119] |
| USP21 | EZH2 | 5637 and T24 cells (bladder carcinoma) |
USP21 overexpression promotes proliferation, invasion and migration | [120] |
#, The cells used were not cancer-derived cells.