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Sequestration of hemolytic erythrocyte components. During hemolysis, the components of RBCs, free hemoglobin and heme, are sequestered by the plasma scavenging proteins, haptoglobin and hemopexin, respectively. The removal of the formed complexes by macrophages and hepatocytes is mediated via the CD163 and CD91 receptors. Under the conditions of erythrolytic stress, macrophages are depleted by intensified erythrophagocytosis that leads to ferroptosis.
