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. 2021 Sep 19;13(18):4696. doi: 10.3390/cancers13184696

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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SREBP2 activation and regulation in physiologically normal cell. Hexagons indicate points of influence by commonly aberrant pathways in PC. Receptor tyrosine kinase (RTK); androgen receptor (AR); glycogen synthase kinase 3 (GSK3), high-density lipoprotein (HDL); low-density lipoprotein (LDL); low-density lipoprotein receptor (LDLR); ATP-binding cassette transporter A1 (ABCA1); ATP-binding cassette transporter G1 (ABCG1); scavenger receptor class B member 1 (SR-B1); insulin-induced gene (INSIG); SREBP cleavage-activating protein (SCAP); site-1 protease (S1P); site-2 protease (S2P); sterol regulatory element–binding protein-2 (SREBP2); sterol response element (SRE). Created with BioRender.com (accessed on 5 September 2021).