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. 2021 Sep 19;13(18):4696. doi: 10.3390/cancers13184696

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cholesterol biosynthesis intermediates and products support prostate cancer growth. Enzymes involved in de novo cholesterol synthesis are indicated in orange. Acetyl-CoA acetyltransferase 2 (ACAT2), 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), mevalonate kinase (MVK), phosphomevalonate kinase (PMK), diphospho-mevalonate decarboxylase(MDD), Isopentenyl-pyrophosphate isomerase (IPP), farnesyl-diphosphate synthase (FDPS), squalene synthase (SQS), squalene monooxygenase(SQLE), sterol regulatory element–binding protein-2 (SREBP2), sterol response element (SRE), isoprenyl-cysteine carboxyl methyltransferase (ICMT). Created with BioRender.com (accessed on 5 September 2021).