Table 2.

Age-specific relative risks associated with age-independent and age-dependent absolute risk thresholds for the high-risk category compared to the population average absolute risk, using remaining lifetime risk and 10-year absolute risk for breast cancer in women in Canada (2012–2016).

	Remaining Lifetime Risk Metric
		Age-independent risk threshold		Age-dependent risk threshold
Current age	Population average remaining lifetime risk %	Remaining lifetime risk threshold for high risk (%)	Relative risk (high risk vs. population average risk)	Remaining lifetime risk threshold for high risk (%)	Relative risk (high risk vs. population average risk)
30	10.1	25.0	2.7	25.0	2.7
35	10.0	25.0	2.7	24.8	2.7
40	9.8	25.0	2.8	24.3	2.7
45	9.3	25.0	2.9	23.2	2.7
50	8.6	25.0	3.2	21.6	2.7
55	7.7	25.0	3.6	19.5	2.7
60	6.7	25.0	4.1	17.1	2.7
65	5.4	25.0	5.2	13.9	2.7
	10-year Absolute Risk Metric
		Age-independent risk threshold		Age-dependent risk threshold
Current age	Population average 10-year absolute risk %	10-year absolute risk threshold for high risk (%)	Relative risk (high risk vs. population average risk)	10-year absolute risk threshold for high risk (%)	Relative risk (high risk vs. population average risk)
30	0.4	1.1	2.7	1.1	2.7
35	0.8	1.1	1.4	2.2	2.7
40	1.3	1.1	0.8	3.6	2.7
45	1.8	1.1	0.6	4.8	2.7
50	2.2	1.1	0.5	5.8	2.7
55	2.6	1.1	0.4	7.0	2.7
60	3.3	1.1	0.3	8.6	2.7
65	3.8	1.1	0.3	9.9	2.7

Relative risks calculated using Equation (1). High risk is defined as remaining lifetime risk (from age 30 to 80 years) of 25%.