Table 4.
Significantly downregulated proteins in CSN38-treated MCF7 cells compared to the monotherapies.
| UniProt ID | HGNC Gene ID | Description | Log2 Fold Change * |
|---|---|---|---|
| Downregulated proteins | |||
| O75363 | BCAS1 | Breast carcinoma-amplified sequence 1 | −27.75 |
| Q9NVH1 | DNAJC11 | DnaJ homologue subfamily C member 11 | −24.68 |
| O00762 | UBE2C | Ubiquitin-conjugating enzyme E2 C | −4.84 |
| O94913 | PCF11 | Pre-mRNA cleavage complex 2 protein Pcf11 | −4.32 |
| A0A1B0GU86 | ACY1 | N-acyl-L-amino-acid amidohydrolase | −4.16 |
| A0A2R8YGD3 | RAPGEF2 | Cyclic nucleotide ras GEF | −2.48 |
| Q9P1V8 | SAMD15 | Sterile alpha motif domain-containing protein 15 | −2.44 |
| Q8TDI0 | CHD5 | Chromodomain-helicase-DNA-binding protein 5 | −2.42 |
| K7ER88 | ACAA2 | 3-Ketoacyl-CoA thiolase_ mitochondrial (Fragment) | −2.05 |
| P20701 | ITGAL | Integrin alpha-L | −2.01 |
| A0A0D9SG95 | CCT7 | T-complex protein 1 subunit eta | −1.78 |
| P03952 | KLKB1 | Plasma kallikrein | −1.72 |
| Q92823 | NRCAM | Neuronal cell adhesion molecule | −1.63 |
| O75582 | RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | −1.56 |
| Q6UXG2 | ELAPOR1 | Endosome/lysosome-associated apoptosis and autophagy regulator 1 | −1.56 |
| Q5H9M0 | PWWP3B | PWWP domain-containing DNA repair factor 3B | −1.47 |
| P55199 | ELL | RNA polymerase II elongation factor ELL | −1.46 |
| Q9NPB8 | GPCPD1 | Glycerophosphocholine phosphodiesterase GPCPD1 | −1.46 |
| Q2TV78 | MST1L | Putative macrophage stimulating 1-like protein | −1.42 |
| A0A0U1RQX8 | CBL | E3 ubiquitin-protein ligase CBL | −1.35 |
| Q6P4H8 | ATPSCKMT | ATP synthase subunit C lysine N-methyltransferase | −1.34 |
| O14513 | NCKAP5 | Nck-associated protein 5 | −1.33 |
| Q8WVV9 | HNRNPLL | Heterogeneous nuclear ribonucleoprotein L-like | −1.32 |
| A0A2R8Y5P9 | SHROOM3 | Protein Shroom3 | −1.22 |
| O43303 | CCP110 | Centriolar coiled-coil protein of 110 kDa | −1.18 |
| Q9C091 | GREB1L | GREB1-like protein | −1.13 |
| Q9BQ52 | ELAC2 | Zinc phosphodiesterase ELAC protein 2 | −1.12 |
| A0A075B757 | NBPF14 | Neuroblastoma breakpoint family member 14 | −1.11 |
| O14497 | ARID1A | AT-rich interactive domain-containing protein 1A | −1.10 |
| Q96C90 | PPP1R14B | Protein phosphatase 1 regulatory subunit 14B | −1.04 |
| Q6IEG0 | SNRNP48 | U11/U12 small nuclear ribonucleoprotein 48 kDa protein | −1.00 |
| Upregulated proteins | |||
| O94973 | AP2A2 | AP-2 complex subunit alpha-2 | 1.20 |
| O14949 | UQCRQ | Cytochrome b-c1 complex subunit 8 | 1.11 |
| A0A1C7CYZ1 | MAPK15 | Mitogen-activated protein kinase 15 (Fragment) | 1.10 |
| Q5T9A4 | ATAD3B | ATPase family AAA domain-containing protein 3B | 1.03 |
| P49189 | ALDH9A1 | 4-Trimethylaminobutyraldehyde dehydrogenase | 1.01 |
*: p and Q ≤ 0.01 alongside maximum Progenesis QIP-calculated fold change ≥ 2 (absolute log2 fold change ≥ 1), compared to the monotherapies (CBD and SN−38); CSN38: the synergistic combination of 42.45 µM cannabidiol and 0.11 µM SN−38.