Skip to main content
. 2021 Aug 25;13(9):2953. doi: 10.3390/nu13092953

Figure 5.

Figure 5

Activity and accuracy in Place Preference Learning (PPL) tasks in IntelliCages. Experiments started 26 weeks after SNI. (A): Time course of Visits, Nosepokes, and Lickings per 12 h intervals of trehalose- and placebo-treated mice (n = 8 per group). The fluctuations show the circadian rhythms. After a short free adaptation (FA), mice were subjected to place preference tasks as depicted in the upper part of the scheme. The drawings show exemplary corner assignments: red for the forbidden corner, green for the rewarding corner(s). Trehalose and placebo were administered via drinking water in rewarding bottles. During FA, all mice received tap water. The observations in IntelliCages were interrupted for 10 days in PPL2/3 to observe reinstatement of the behavior after a home cage interval. (B): Time course of the proportion of correct visits in PPL tasks as depicted in A. Data are the means and sem and were compared with 2-way ANOVA for “time” x “treatment” and subsequent post hoc analysis for trehalose versus vehicle. Asterisks show p-values < 0.05.