Table 2.

Results from statistical analysis of differences in icobrain ms volumetrics between MS types. The group effect rows provide the results of the Kruskal–Wallis analyses looking for an effect of MS type on these variables. Other rows indicate the group differences as observed via post-hoc pairwise tests. p-values have been corrected for multiple comparisons.

	Whole Brain	Gray Matter	Lateral Ventricles	FLAIR Lesions	T1 Blackholes
EDSS ≤ 4
Group effect	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001
CIS vs. RRMS	p = 0.008	p = 0.258	p = 0.029	p < 0.001	p < 0.001
CIS vs. SPMS	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001
CIS vs. PPMS	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001
RRMS vs. SPMS	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001
RRMS vs. PPMS	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p = 0.173
SPMS vs. PPMS	p = 0.935	p = 1.000	p = 1.000	p = 0.902	p < 0.001
EDSS > 4
Group effect	p = 0.013	p = 0.072	p = 0.014	p = 0.013	p = 0.054
RRMS vs. SPMS	p = 0.005	p = 0.073	p = 0.006	p = 0.034	p = 0.101
RRMS vs. PPMS	p = 0.007	p = 0.094	p = 0.027	p = 0.716	p = 0.662
SPMS vs. PPMS	p = 0.992	p = 1.000	p = 0.955	p = 0.033	p = 0.251