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NTPDase1/CD39 and vascular inflammation. After tissue damage, levels of extracellular ATP strongly increase, contributing to boost inflammation, and together with ADP promote platelet activation and aggregation (red lines). Endothelial cell CD39 by hydrolysing ATP to ADP and to AMP, reduces ADP concentrations at the site of injury. CD73 then hydrolyses AMP to adenosine, that inhibits platelet aggregation and reduces inflammation (green lines), providing to maintain tissue homeostasis.
