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. 2021 Aug 27;10(9):2223. doi: 10.3390/cells10092223

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Targeting NTPDase1/CD39 in thrombosis. (A) Recombinant soluble CD39 (solCD39) [39,53,94] through its ATPase and ADPase activities inhibits ADP-mediated platelet activation and aggregation. (B) CD39, fused with a single-chain antibody (scFv) specific for GPIIb/IIIa [94,95,96], expressed on activated platelets, contributes to reduce ADP concentration, providing strong anti-thrombotic effects. (C) The glycoprotein VI (GPVI)Fc-fusion protein is combined to soluble CD39 [97]. The GPVI-Fc inhibits the interaction of GPVI expressed on platelets with vascular collagen in plaques while CD39 reduces the concentrations of ATP/ADP, resulting in a strong inhibition of platelets adhesion and aggregation.