Table 1.

Summary of the biological role of EVs in lung cancer.

Related Molecules in EVs	Influenced Molecules	Function	References
miR-21	VEGF	Enhance the VEGF and angiogenesis	[19]
Exosome-derived lung cancer	NF-ĸB-TLR signaling	Mesenchymal stem cells can be transformed into a pro-inflammatory phenotype	[20]
EGFR		Stimulate tumor-specific regulatory T cells that can limit the role of anti-tumor CD-positive T cells	[21]
Exosome-derived lung cancer		Induce EMT in human bronchial epithelial cells	[22]
Integrin α6β4 and α6β1		Organ-specific lung metastasis	[24]
miR-222-3p		Promote gemcitabine resistance	[25]
EGFR		Inhibit function of CD-positive T cell	[21,26]
PD-L1	PD-1	Avoid immune surveillance and CD8+ T cells	[27,28]
Exosome-derived lung cancer	CCR6, CCR7 and CXCR3	Inhibit migration of DCs	[29]
Exosome-derived lung cancer	STAT3, IL-4Rα-STAT6 pathway	Expand MDSCs and suppress T cell function	[30]
Hsp72	TLR2/My88 signaling pathway	Activate MDSCs	[31]
miR-21	Akt	Gefitinib resistance	[32]