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. 2021 Sep 16;10(9):1477. doi: 10.3390/antiox10091477

Figure 7.

Figure 7

The potency of polydatin to assuage resistance of 5-FU in colon cancer cells. (A) Antiproliferative effect of polydatin in 5-FU-R cells with or without 5-FU. (B) Effect of 72-h treatment with a combination of polydatin and 5-FU on spheroids formation in 5-FU-R cells. Scale bar: 100 µm. (C) Apoptotic effect of polydatin in 5-FU-R cells with or without 5-FU, as elucidated by Annexin V and PI staining. (D) In 5-FU-R cells, effects of polydatin on the protein expression of TYMS and apoptosis-related factors with or without 5-FU, as determined by Western blotting. The asterisks symbolize significant differences among various groups (* p < 0.05, ** p < 0.01, and *** p < 0.001).