Table 7.
Vitamin E effects on selected parameters of hyperthyroid-induced animal models.
| Species | Organ | Investigated Effect | Results | References |
|---|---|---|---|---|
| rat | renal cortex | oxidative stress parameters (lipid peroxidation and protein carbonylation) and small antioxidant molecules (reduced glutathione and ascorbic acid); antioxidant enzymes activities (i.e., SOD, CAT); translated product of Cu/Zn-SOD, Mn-SOD | Restoration of oxidative stress parameters and small antioxidant molecules levels; ↓ in translated product of Cu/Zn-SOD, Mn-SOD and CAT |
[64] |
| rat | liver | hepatic function; hepatic complexes I and II mediated respiration and hepatic oxidative stress (protein carbonylation) | amelioration of hepatic function; ↓ state 4 respiration of complex I; ↑ complex II respiration both at state 3 and state 4 level; ↓ protein carbonylation |
[65] |
| rat | liver | antioxidant genes (AOG) expression | alleviated message levels of SOD and CAT; ameliorated GPx1 and GR mRNA levels; alleviate SOD1, CAT and GR translated products; normalization mitochondrial SOD1 |
[66] |
AOG: antioxidant genes; CAT: catalase; SOD: superoxide dismutase.