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. 2021 Sep 12;13(18):4580. doi: 10.3390/cancers13184580

Table 5.

Risk factors for renal insufficiency.

Renal Insufficiency
No
n = 309
Yes
n = 41
OR 95% CI p
n (%) n (%)
Cisplatin dose
 low-dose 1 217 (92.7) 17 (7.3)
 high-dose 92 (79.3) 24 (20.7) 2.73 1.33 5.63 0.006
Chemotherapeutic agents
 cisplatin 1 194 (91.5) 18 (8.5)
 cisplatin and doxorubicin 115 (83.3) 23 (16.7) 0.67 0.26 1.71 0.402
Resection method
 P/D
 eP/D
 EPP 1

69 (89.6)
233 (88.6)
7 (70.0)

8 (10.4)
30 (11.4)
3 (30.0)

0.46
0.85

0.09
0.19

2.25
3.73

0.335
0.827
Induction chemotherapy
 no 1 207 (90.0) 23 (10.0)
 yes 102 (85.0) 18 (15.0) 1.04 0.50 2.19 0.913
Cytoprotection
 no 1 162 (94.2) 10 (5.8)
 yes 147 (82.6) 31 (17.4) 8.36 2.37 29.49 0.001
Perioperative fluid balancing
 no 28 (82.4) 6 (17.6)
 yes 1 281 (88.9) 35 (11.1) 6.33 1.57 25.45 0.009

The results of multivariable binary logistic regression analysis (Χ2 = 31.3, p < 0.001, Nagelkerkes R2 = 0.166) and descriptive distribution of risk factors for renal insufficiency are presented. 1 reference category.