Table 3.

Multivariate bivariate correlation analysis of factors associated with voriconazole plasma concentration.

Variable	Coefficient	p-Value
Age	−0.064	0.485
Sex	0.221	0.015 *
Weight	0.001	0.993
Daily dose	0.329	<0.001 *
CYP2C19 genotyping 1
*1/*2	−0.068	0.417
*1/*3	0.196	0.018 *
*2/*2	0.216	0.009 *
Platelet	−0.302	0.001 *
INR	0.184	0.047 *
PTA	−0.278	0.002 *
MELD score	0.184	0.048 *
Hemoglobin	−0.063	0.518
Alanine aminotransferase	−0.037	0.696
Aspartate aminotransferase	0.051	0.588
Total bilirubin	0.104	0.265
Direct bilirubin	0.092	0.324
Bile acid	0.016	0.862
Albumin	0.153	0.101
Blood urea nitrogen	0.058	0.532
Creatinine	0.044	0.638
Creatinine Clearance	0.010	0.915
Prothrombin time	0.153	0.100
Artificial extracorporeal liver	0.044	0.635
Concomitant agents 2
CY2C19 inhibitors	0.048	0.609
Antimicrobial agents	−0.010	0.919

¹CYP2C19 genotyping was dealt with the operation of dummy variables compared to CYP2C19*1/*1. We considered the patient with CYP2C19 *1/*17 (n = 1) within the same group as the CYP2C19*1/*1. ² CYP2C19 inducers were not analyzed as only one patient applicated. IQR, interquartile range; PTA, prothrombin time activity; INR, international normalized ratio; MELD, Model for end-stage liver disease. p < 0.05 and variables with statistical significance are expressed as *.